Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. [5]Wawrzynska L, Sakowicz A, Rudzinski P, Langfort R, Kurzyna M: The conversion to triiodothyronine in the lung: comparison of activity of type I iodotironine 5 deiodinase in lung cancer with peripheral lung tissues. The authors of the study pointed out that levothyroxine (T4) treatment can lead to medication-induced (iatrogenic) thyroid over-activity (hyperthyroidism) and oxidative stress that can lead to a significant patient discomfort. Cancer Risk After Radioactive Iodine Treatment for - PubMed Merck Announces Phase 3 KEYNOTE-671 Trial Met Primary Endpoint of Event There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a TSH suppressor. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic self-fulfilling prophecy if you will. millions treated for hypothyroidism at risk for lung cancer When a high-risk patient presents with one or more lung nodules, the path ahead and next steps seems obvious. Iodine - and the lack of it - is implicated in breast cancer, after all. Due to excessive bot signups along with nefarious actors we are limiting forum registration. rocket fuel, pesticides, fluoride, which induce low thyroid function. The great open sky of imagination: for those who u Fermented Foods: Top 8 Reasons to Eat Them. JavaScript is disabled. In my view the paper isn't worth the pixels used to display it on a screen. They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. PMID 11836274. Article published in Wakeup-World.Com. As I am the caregiver for my dad who has Stage IV lung Cancer, I hope more research can be done on this topic soon. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer If people do not wish to find out all they can about their disease that is fine too. Patients with incomplete information (n = 127), preexisting hypothyroidism or levothyroxine replacement before initiation of ICI therapy (n = 11), or other factors known to contribute to thyroid dysfunction after immunotherapy (n = 17) were excluded (Fig. Thyroid dysfunction after immune checkpoint inhibitor treatment in a I honestly do not know. Monaldi Arch Chest Dis 2003, 59:140145. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. LOL. Most of the time, doctors tell patients treated with LT4 that any side effects will be temporary and almost ineluctable, and are usually dealt with through dose reduction. En 3 minutos recibirs en tu email COMPLETAMENTE GRATIS todo lo que necesitas para aumentar las ventas de tu empresa. Study: Millions Treated for Hypothyroidism at Risk of Lung Cancer Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. In addition, untreated hypothyroidism is associated with a gradual decline in cognitive function and memory. I cried with joy when I found out there was something really wrong with me. Just another excuse for keeping us on doses that are too low. Biomedicine today is awash in controversy associated with the overdiagnosis and overtreatment of asymptomatic populations. Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. Sub-laboratory hypothyroidism and the empirical use of Armour thyroid. Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. For more information, please see our Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. The reality is that most cases of hypothyroidism today are diagnosed in populations who are experiencing a combination of basic nutritional deficiencies and chemical exposures, or who are simply going through a temporary down-cycle in thyroid function following a natural change, such as the natural postpartum drop that occurs in women after giving birth. The Flu Propaganda Matrix Continues To Promote Fea B Vitamins Slow Alzheimer's and Grey Matter Loss. The Goji Berry: The Jolly Super Food That Gives Yo How to Prevent and Treat Insect Bites Without Hars Supreme Court Rules Drug Companies Exempt From Law Spain Study Confirms Hemp Oil Cures Cancer without Wheatgrass Turns Gray Hair Back to Its Natural Color, Medicinal Cannabis Used To Prevent Cancer Growth. Epub 2013 Mar 28. Log In. Another recently approved drug is tepotinib (Tepmetko). Cookie Notice I will respond more later onBut I will briefly say I was on Synthyroid from 1993 to 2011. A study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' However, they pointed out that the opposite was actually described, and that hypothyroidism reduces the aggressiveness of some cancers because of the presence of thyroid hormone receptors on cancer cells, and spontaneous hypothyroidism may delay onset or reduce aggressiveness of cancers.[1]. millions treated for hypothyroidism at risk for lung cancer Hypothyroidism can also lead to swelling of the tongue, hoarse voice, and sleep apnea. "Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)". I wonder if only t3 treatments are preferable than t4 and t3 ? By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. In comparison, 62.4% of female and 37% of male . [14] K A Woeber. It does not necessarily imply one thing caused the other. Or, simply look at what the young-adult,T-score based definition of osteoporosis and osteopeniahas done to convert millions of healthy middle-age and older women into drug-treatable patients, or, what the lipid hypothesis of cardiovascular disease causation has done to create a 30-billion dollar a year market in statin drugs, to fully appreciate the harms of overdiagnosis and overtreatment. hyperthyroidism. They also noted that oxidative stress is one of the causes of chronic diseases and cancer. One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore 'back up' causing excessive T4 activity, i.e. I do not believe in random events, of nature or otherwise. The estimated 2.3 million new cases indicate that 1 in every 8 cancers diagnosed in . [8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. The authors delved deeper into the reason why oxidative stress taking place during T4 treatment is particularly linked to lung cancer only: The hypothesis could be that in lungs the increase of hypoxia-induced factor (HIF-1) which is determined by T4 can make oxygen much more available, increasing locally the oxidative stress together with a dangerous angiogenesis stimulation. There are several books out there written about the topic. [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. [14] In other words, you can 'normalize' the main clinically measurable parameter associated with 'low thyroid function,' i.e. There is also compelling research indicating that desiccated thyroid extract (Armour thyroid) results in superior clinical outcomes versus the synthetic hormone, especially as concerns improved body weight. Medical Authoritys System Kills: FDA-Approved Dru Cognitive Impairment, Memory Loss and Alzheimer's Soy Lecithin: How It Negatively Affects Your Healt Cannabis Oil Cures Cancer -Lincoln Horsley's Story New Information Dissolves Illusions About Vaccines Grounding Helps Thin Dangerously Thick Blood and F Tart Cherries Relieve Osteoarthritis Pain, Lieberman's Massive Connections To Big Pharma, Utopian 'Harvest Your Own' Groceries Coming Up. Thanks, I am not suggesting I believe in all that I see. Based just on this article, I think the study's conclusion that Synthroid may cause an increase in lung cancer risk is premature. Find how some diseases can be healed with alternative medicine, and share your experience with I bet in the previous discussion, if there was one, we would have concluded it was likely that it was because people are generally not put on enough levothyroxine. Study: Millions Treated for - Healing Lyme Disease | Facebook PLoSone 2011, 11:e27547. I was sure that the paper had been discussed here shortly after publication in 2013, but cannot find the thread! Marketed as superior to traditional glandular forms extracted from pigs (whose endocrine glands are far more bioidentical than any other animal we know of) due to the dose-to-dose standardization of the so-called active ingredient T4 versus the natural variations in hormone concentrations found in the real thing, which incidentally contains a wide range of additional hormones including T1, T2, T3, all of which are vitally important. I hope that with increased knowledge we will all find the right road. "A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' Keep checking back for the register link to appear. People read a study and think that someone like, perhaps me, is saying "it Causes lung cancer. Results indicate that treatment with levothyroxine was linked with significantly increased mortality (hazard ratio = 1.19). Savvy Senior: Could you have a thyroid problem and not even know it? Curr Opin Endocrinol Diabetes Obes 2010, 17:432436. Respiratory function in thyroid disease - UpToDate Data sources: The Medline and Cochrane Library electronic databases . Levothyroxine is a widely prescribed medication for the treatment of an underactive thyroid. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as "hypothyroidism"? millions treated for hypothyroidism at risk for lung cancer Also this study finds no link with breast cancer, when others have found a link. ', Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer. ", Orsomeone posts something about, say a diet or supplement and them some people think they are something it "Cures lung cancer.". UpToDate Acta Endocrinol 1988, 118:460464. Correlation is when two things seem to happen at the same time, in the same place, and/or in the same population. ", That study is like a fishing expedition. I very much appreciate the information you shared. It's usually based on the results of blood tests. According to data from the National Health and Nutrition Examination Survey, years 1988-1994, [13] while 0.3% of the American population exhibits overt symptoms of hypothyroidism, 14 times more (4.3%) have so-called 'subclinical' hypothyroidism only detected via blood work. Marketed as superior to traditional glandular forms extracted from pigs (whose endocrine glands are far more bioidentical than any other animal we know of) due to the dose-to-dose standardization of the so-called 'active ingredient' T4 versus the natural variations in hormone concentrations found in the 'real thing,' which incidentally contains a wide range of additional hormones including T1, T2, T3, all of which are vitally important. Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. El almacenamiento o acceso tcnico es estrictamente necesario para el propsito legtimo de permitir el uso de un servicio especfico explcitamente solicitado por el abonado o usuario, o con el nico propsito de llevar a cabo la transmisin de una comunicacin a travs de una red de comunicaciones electrnicas. Also, what is oxidised stress??? [6] Venditti P, Di Stefano L, Di Meo S: Oxidative stress in cold induced hyperthyroid state. [3]Faber J, Poulsen S, Iversen P, Kirkegaard C: Thyroid hormone turnover in patients with small cell carcinoma of the lung. I read somewhere about the work done many years ago which was mistakenly read and accepted 28 y/o F Low levels across the board for TSH, T3, and T4, Acid reflux drug linked to more than doubled risk of stomach cancer study, thyroiduk.org - further-reading - thyroid-diagnosis-and-treatment. I don't believe there are thousands of people on to high a dose of t4, so why does it feel they are hyper? This website is for information purposes only. That's all. Cancer-related fatigue (CRF) is common in lung cancer survivors and can occur at any point in the care continuum. If it's high, the test is done again, along with a blood test for the thyroid hormone T-4. Study: Millions Treated for Hypothyroidism At Risk of Lung Cancer. Respiratory system Hypothyroidism weakens the respiratory muscles and decreases lung function. Dr Childs guesses that patients on levothyroxine monotherapy may be more prone to cancer because they might be under-treated. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: "[I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. Now, I will bring it to the attention of my Endocrinologist. (They noted that this age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers). Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the "low thyroid," why call chemical poisoning "hypothyroidism"? [14] In other words, you can normalize the main clinically measurable parameter associated with low thyroid function, i.e. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' Millions of people who were not only wrongly diagnosed with 'cancers' and subsequently aggressively treated for them with chemotherapy, radiation and surgery, are now being told that they would have been better left undiagnosed and untreated. Thank you for posting it, I agree we all need as much knowledge as we can get! Garlic Beats Drug in Detoxifying Lead Safely From How Yoga and Acupuncture Enhance HealthNew Resear Health Nuts: Seeds And Nuts You Should Eat Every Day. The increasingly global medical-industrial complex has begun to co-opt all aspects of the natural human bodily life cycle, and all the organ systems within it, as potential targets of medical surveillance and intervention, not excluding the human thyroid. [2] Meng R, Tang HY, Westfall J, London D, Cao JH, Mousa SA, Luidens M, Hercbergs A, Davis FB, Davis PJ, et al: Crosstalk between integrin v3 and estrogen receptor- is involved in thyroid hormone-induced proliferation in human lung carcinoma cells.